Hyaluronic acid is known to be metabolized. Since hyaluronic acid is injected into the body, it is slowly metabolized by the body’s hyaluronidase (hyaluronidase) enzyme until all of it is metabolized. Current research suggests that the following factors are closely related to the rate of hyaluronic acid metabolism. 1.Individual differences (body mass index and age) Overall, the metabolic rate of hyaluronic acid is higher for people with low body fat index than for obese people; meanwhile, the metabolic rate of hyaluronic acid will be gradually accelerated with age, which is because the content of hyaluronic acid in aging tissues is at a lower level, so its metabolic rate is higher after injection, and the maintenance time will be relatively shorter. 2.Life habits (sports, drinking and staying up late) Drinking alcohol and sports will accelerate blood circulation, which will increase the metabolic rate of hyaluronic acid; staying up late will lead to loss of skin moisture, which will also increase the metabolic rate of hyaluronic acid. 3, the activity of the injection site Usually the metabolism of hyaluronic acid is slower in parts of the body with less activity, such as the nose and chin, while the metabolism of hyaluronic acid is more rapid in areas with rich expressions, such as the lines, apple muscle and lips. In contrast to the penis, the metabolism rate of hyaluronic acid is relatively high for men with an active sex life because of their greater local activity. 4.Type of hyaluronic acid Hyaluronic acid can be divided into three types: large, medium and small molecules, and its metabolic rate will increase in turn, which is mainly related to the proportion of cross-linking agent in the product. 5.Subjective feeling One week after the injection of hyaluronic acid, due to its strong water absorption effect, the injection site will show obvious edema. After a week, the edema gradually subsides, at which time many partners will think that hyaluronic acid is absorbed, which is actually a subjective illusion, and the absorption of hyaluronic acid cannot reach such a high rate. According to the literature and my personal experience, the maintenance time of hyaluronic acid for penile enlargement is generally about 2 years, which is of course the average; if the injection dosage is larger and large molecules of hyaluronic acid are used, the maintenance time will be longer. From this result, it can be seen that at the 48-week follow-up after injection, the circumference of the penis root, middle and near the coronal sulcus did not change significantly compared to the immediate post-injection period, and the largest reduction was only 9.5%, indicating that the rate of metabolism was not very fast. For penile enlargement injections, how can we prolong the effect of hyaluronic acid filling? In my opinion, hyaluronic acid metabolism is a natural process and there is very little that individuals can do subjectively. First of all, there is no need for us to gain weight, reduce physical activity or downsize our sex life in order to slow down the metabolism of hyaluronic acid. What we can do includes avoiding alcohol and staying up late, maintaining a healthy lifestyle, in addition to the choice of injection materials, we can consider large molecule products and increase the amount of hyaluronic acid injected under the premise of following a harmonious beauty.