The two major classes of recognized effective antiviral drugs are interferon analogs and nucleoside (acid) analogs: interferons include regular interferons: IFN1b, IFN2a, IFN2b and pegylated interferons: Pyroxin (40KD) PegIFN-2a, Pellegrin (12KD) PegIFN-2b, with a 1-year course of treatment, HBeAg-negative patients are prone to relapse after discontinuation of the drug. The course of treatment should be extended. There are 4 nucleotide analogues listed in China, each with its own characteristics. 600mg qd, can cause an increase in serum creatine kinase (CK); entecavir (entecavir): 0.5mg qd, strong viral inhibitory activity, low incidence of drug resistance, high price.