Topical medications for treating gray nails include Ciclopirox Application and Amorolfine Hydrochloride Application. Gray nail is usually caused by dermatophyte infection, which is manifested as cloudy, separated, thickened, uneven and peeling nail plate. 1. Ciclopirox application: it has strong antibacterial effect on dermatophytes, and it can be applied externally to gray nails, which can play the role of antibacterial and bactericidal. Before use, it should be noted that it is forbidden for those who are allergic to cyclopiazone application and children under 6 years old, and during the process of use, when it comes into contact with the skin near the nails, adverse reactions such as reddening of the skin and peeling of the skin may occur. 2. Amorphophallus Hydrochloride Application: It is a topical antifungal drug with antibacterial and antiseptic effects, which is effective in the treatment of gray nails. It should be noted that it is forbidden for those who are allergic to any ingredients of Amorphophallus Hydrochloride Application and pregnant women, and itchiness, peeling, burning sensation and other adverse reactions may occur on the skin around the nail bed in the process of use. All of the above drugs may have adverse reactions, and it is recommended that they be used under medical supervision. Gray nail external drug penetration is limited, the clinical generally oral drug treatment, patients are recommended to go to the regular hospital for treatment.