Neonatal hemolytic jaundice is jaundice caused by homozygous immune hemolysis due to mother-child blood group incompatibility, of which ABO blood group incompatibility is the most common and Rh blood group incompatibility is less common. Treatment of hemolytic jaundice in newborns, including light therapy, drug therapy, blood exchange therapy, other treatments, etc., as follows: a. Light therapy: this is a simple and effective way to reduce unconjugated bilirubin in the serum. Second, drug therapy: according to the condition, choose albumin, immunoglobulin, liver enzyme inducers and other drug therapy. Third, blood exchange therapy: it can exchange the free antibodies and sensitized red blood cells in the blood to reduce hemolysis, and at the same time, it can exchange a large amount of bilirubin in the blood to prevent the occurrence of bilirubin encephalopathy. Fourth, other treatment: to prevent the occurrence of hypoglycemia, hypocalcemia, hypothermia, electrolyte disorders and heart failure, etc.