Bilirubin is one of the common indicators of liver function tests. Bilirubin indicators include total serum bilirubin, conjugated bilirubin, unconjugated bilirubin, and can also be determined by testing urinary bilirubin to determine whether bilirubin is elevated. When hemolytic anemia, Gilbert’s syndrome (congenital non-hemolytic jaundice), various types of hepatitis, biliary inflammation, etc. can lead to impaired bilirubin metabolism, which is clinically classified into physiological and pathological conditions: 1. Possible causes of physiological high bilirubin include: neonatal jaundice, strenuous exercise, excessive fatigue, excessive alcohol consumption, and other physiological factors can lead to elevated bilirubin. 2, pathological high may be caused by: (1) liver disease: such as acute jaundice hepatitis, viral hepatitis, drug or toxic hepatitis, acute alcoholic hepatitis, liver cirrhosis, liver cancer, etc. (2) Biliary system diseases: such as cholelithiasis, bile duct tumor, etc. (3) Other diseases: such as pancreatic head cancer, hemolytic anemia, congestive heart failure and alkalosis, etc., can lead to increased bilirubin. If the bilirubin is elevated, it is recommended to seek medical attention in a timely manner and do further relevant examinations to clarify the cause and carry out symptomatic treatment, do not neglect and delay the condition.