Recently, two SLE patients got pregnant, which is undoubtedly very good news for the patients and their families, but at the same time, the patients are also worried about the relapse and aggravation of their disease and their children. After coming back from the clinic with limited time, we organized the following information and suggested the following: I. Pregnancy checkup 1. Evaluation of lupus activity, organ involvement, laboratory tests, drugs used. History collection: duration of disease, organs involved, time in remission, typical signs and symptoms at previous relapses, current clinical symptoms, previous and current medications, previous pregnancy and childbirth history. Physical examination: including blood pressure (blood pressure needs to be taken at each examination). 2. SLE pregnancy check-up plan – standard follow-up interval 1-28w: every 4w 28-36w: every 2w follow-up. After that: 1 follow up every week. 3.Pregnancy checkup plan Maternal checkup. Assessment of hypertensive complications of pregnancy, APS and lupus disease activity. Laboratory tests: CBC; urine routine, sediment, 24h urine protein quantification, CCr; complement, anti-dsDNA. Fetal monitoring. II. How to identify physiological changes in pregnancy, complications and lupus activity Mildly decreased PLT is seen in about 8% of normal pregnancies. A significant decrease in PLT can be seen in active lupus, severe pre-eclampsia or HELLP syndrome and requires specialist evaluation. Varying degrees of anemia-approximately 50% of healthy pregnant women. Estrogen stimulation of liver synthesis during pregnancy may increase complement C3 and C4, which may mask the activity of SLE, so a comprehensive assessment based on clinical manifestations is needed. Treatment of lupus relapse No signs of lupus activity, no special treatment is needed. In the first 3 months of pregnancy, significant disease activity requires termination of pregnancy. If the disease is active after the third month of pregnancy, the hormone dose can be increased to control the disease. Mild activity: low dose of prednisone (less than 20 mg/d). Moderate activity: high dose. Severe disease: IV methylprednisolone shock. Prednisone >10mg/d may increase the incidence of pre-eclampsia, hyperemesis, gestational diabetes, infection and premature rupture of membranes and should be maintained at the lowest possible dose. Prevention and control of postpartum lupus recurrence The disease often worsens after delivery, and the high levels of lactogen and estrogen in the body are related to miscarriage, stillbirth, and overexertion, which can cause the disease to recur and worsen. Evaluate the disease activity of SLE in January, March and June after delivery.