Gray nails are caused by fungal infection of the nail plate and nail bed, so the application of antifungal drugs is more effective. There are more antifungal drugs for the treatment of gray nails, which are clinically divided into two categories: oral drugs and topical drugs. The drug is not allowed during pregnancy because of the possibility of fetal defects, and it is absorbed well and the incidence of adverse reactions is low. The actual topical medication: for more limited gray nails can be topical glacial acetic acid, tincture of iodine or amorolfine application. The actual nail is removed before the drug is applied, and then the drug is applied to facilitate the absorption of the drug. You can also apply salicylic acid ointment, urea ointment topical and bandage, the diseased nail softened peeled and removed, and then continue to apply topical drug treatment. The treatment of gray nail takes longer and is more difficult to cure completely. Patients should adhere to the standard medication under the guidance of a doctor, such as oral antifungal drugs, should regularly review the blood routine, liver and kidney function, and should seek medical help in time if liver and kidney function damage occurs. If the application of the above drugs is ineffective, or if the symptoms of separation of the nail bed and nail have appeared, it is recommended to seek medical attention and perform nail extraction surgery. Patients should pay attention to daily care, regularly sterilize personal clothing, shoes and socks, wash feet with warm water every day, keep feet dry, inhibit fungal growth, and avoid incomplete treatment and cross-infection.