Twitching during sleep is common in the following diseases: first, patients with epilepsy, seizures during sleep will be manifested as twitching during sleep, and EEG examination can make a clear diagnosis. Second, patients with hypocalcemia, due to the low concentration of calcium ions in the body will lead to excessive excitability of peripheral nerves, twitching of hands and feet will occur in sleep, especially in the elderly after the lower extremities are cold, more likely to appear the symptoms of twitching in sleep, calcium ion concentration tests and bone density tests can be performed to clarify the diagnosis. Third, when hypertension is combined with cerebral hemangioma, it is easy to have cerebral hemangioma rupture and bleeding during sleep, and the blood clot will compress the surrounding brain nerves and cause convulsions, accompanied by coma and drowsiness. Fourth, patients with third-degree atrioventricular block and other bradycardia may suffer from insufficient blood supply to the brain due to slower heartbeat during sleep, which may lead to convulsions during sleep and other symptoms of A.S. syndrome, and can be diagnosed by performing ECG monitoring or dynamic ECG examination.