The common cause of constant twitching and pain in the inner thigh is spasm of the internal femoral retractor muscle. Spasm of the internal femoral retractor muscle is caused by the patient’s frequent overexertion or the occurrence of cumulative injury to the internal femoral retractor. Patients usually have no obvious history of trauma, pain occurs in standing or squatting position, pain and twitching symptoms are relieved in the morning, but there is a feeling of stiffness, and twitching pain symptoms are aggravated in the afternoon or after exertion. Physical examination may be obvious in the internal femoral muscle group with tenderness, active or passive lower extremity abduction, which also induces pain and twitching symptoms, while the internal femoral muscle spasm and tension may be obviously perceived. Treatment methods, including manual massage, massage, and hot water bath therapy, can relax the tension, spasm, and stiffness of the internal femoral muscle, and improve local blood circulation.