Twitching of the calf while sleeping is usually a painful muscle spasm that has occurred. Typical symptoms are muscle stiffness and tension at the calf belly, gastrocnemius muscle, pulling-like pain or soreness, kneading the leg or pounding the leg, which can help the pain relief. This condition, mostly seen in menopausal women, generally has symptoms such as low calcium and osteoporosis. It is recommended to visit neurology, and endocrinology, and after it is clear that it is calf muscle spasm, it can be treated symptomatically with calcium supplementation. Generally, chewable calcium vitamin D tablets are commonly used, 2 tablets once a day, and can be taken for a long time. In terms of examination, blood electrolyte examination can be improved to clarify whether there is low calcium and the degree of low calcium, bone density examination can also be improved to clarify whether there is osteoporosis, and endocrine examination can also be improved to clarify whether there is estrogen and progesterone abnormalities.