Pustular acne can be treated with topical antibiotic medications, as well as oral antibiotics and isotretinoin. If acne is pustular, it is usually a bacterial infection and can be treated with topical antibiotics, including fusidic acid cream, mupirocin ointment, and erythromycin ointment. In addition, oral antibiotics such as minocycline hydrochloride and metronidazole can be taken when acne symptoms are severe. Oral isotretinoin can also be taken to reduce sebum secretion, thus reducing acne. If acne symptoms are severe, you should go to the hospital in time and follow the doctor’s instructions when using the above medications.