Every year during the summer after the entrance exams, the waiting area of the hospital’s puberty clinic is filled with middle-aged mothers and fathers accompanying girls of 17 or 18 years old sitting uneasily in the waiting area. Most of these girls get their periods after the entrance exams when they shouldn’t, or they are late in coming when they should. Why is this? Psychological stress is the cause of the disease. Lele, a girl in her senior year of high school, is one of them. She was sitting quietly on a chair, her face was not as rosy as is common for adolescent children. Lele’s mother told me that the child’s physiological period just before the entrance exam was clean, three days after the entrance exam came again, and this came dripping for more than a week has not been clean. After the college entrance exams, girls with abnormal menstruation are often ashamed to talk about it, some are busy with the college entrance exams and filling out the volunteer after the entrance exams, and have been bleeding, some to anemia or even shock before coming to the doctor. I gave Lele a detailed consultation and gynecological endocrine examination. Lele’s anemia was not obvious, and there was no organic disease in the uterine adnexa. I told Lele’s mother that Lele’s condition was a situation that occurs in many high school girls: abnormal menstruation due to the stress of the entrance exams. The psychological stress caused by the entrance exams and the admissions process after the exams can lead to lack of sleep and little time for physical exercise, which can also affect the nerve center of the brain and cause the pituitary gland to “mess up” the instructions to the ovaries, resulting in abnormal menstruation in girls. The girl and her parents should pay attention to this situation, but do not have to be too nervous. Parents should take their children to the gynecological puberty clinic in time for consultation. After a comprehensive examination to rule out other diseases that cause abnormal vaginal bleeding, the child can resume normal regular menstruation with the help of the doctor; parents who are too nervous will add to the child’s burden of thinking and affect the adjustment and recovery of the gonadal axis. In the face of abnormal menstruation in high school girls, the adolescent clinic doctor will also routinely ask the child if sexual activity has occurred so as not to miss the possibility of miscarriage or ectopic pregnancy. It is not uncommon for high school students to face pressure and not be able to grasp the feelings between male and female classmates to have sex. Parents should face this calmly, respect their children, understand the doctor’s questions, and if necessary, the doctor will tell their children how to protect themselves from a health perspective.