Menstruation for 2 months did not come and not pregnant, when this situation, consider physiological factors, endocrine disorders, reproductive system diseases, etc., should be based on the signs and test results of the joint judgment, clear reasons for active treatment. I. Physiological factors: women aged 10-18 years old is the period of development of secondary sexual characteristics, during this period there will be menstruation, but due to the gonadal axis is not well developed, there may be irregular menstruation, you can continue to observe menstruation, and if the menopause persists, you can check the level of sex hormones and the development of the gonads; after the age of 45 years old, women’s ovarian function gradually declines, and perimenopausal phenomenon occurs, which may be accompanied by panic, fatigue, and so on, and generally do not need special treatment. It is generally not necessary to take special treatment. Second, endocrine disorders 1, functional endocrine disorders: often caused by staying up late, bad moods, excessive stress, etc., in addition to early menstruation, but also poor skin condition, poor mental health, loss of appetite, etc., the need for timely adjustments to lifestyle, improve bad habits, if necessary, psychological intervention; 2, organic endocrine disorders: most often due to endocrine organ dysfunction caused by diseases, such as hyperthyroidism, diabetes, pituitary tumors, etc., can be found in the endocrine organs, Diabetes mellitus, pituitary tumors, etc., can lead to estrogen disorders, menstrual disorders, delayed or early, usually need to treat the primary disease, can be supplemented with sex hormones to treat menstrual disorders. Third, the reproductive system diseases 1, polycystic ovary syndrome: the main clinical manifestations of patients with amenorrhea, infertility, hirsutism, acne, etc., oral short-acting contraceptives, glucocorticoids, etc., can improve the symptoms, laparoscopic ovary electrocautery or laser perforation treatment, some patients can restore the function of pregnancy; 2, gynecological inflammation: such as pelvic inflammatory disease, vaginitis, cervicitis, etc., can be manifested as lower abdominal pain, fever, vaginal discharge, and the prolonged course of the disease, menstrual irregularities, and the increase of vaginal discharge, the increase of vaginal discharge. The prolonged course of the disease appears irregular menstruation. Fourth, other diseases such as malnutrition, severe anemia, premature ovarian failure, ovarian functional tumors, etc., can lead to menstrual disorders, and need to consult a doctor in time to treat the original disease.