Outpatients often encounter healthy, active, but slightly nervous older children who come to the clinic, often with a problem of enuresis upon inquiry. Most of these children are 7-9 years old and have typically started wetting the bed from a young age, with good control of urination during the day and no constipation or soiled stools. Detailed examination reveals that the vast majority of children have occult spina bifida, but no spinal cord embolism, and the urinary system and rectal and anal examinations are normal. Although enuresis is not a serious condition, it can be quite annoying for parents and the child. Especially when the child goes to school, it is difficult to participate in some group activities organized by the school for fear of being laughed at by other children, which leads to loneliness, shyness, lack of confidence and other negative psychological reactions. Under normal circumstances, people have 2 centers for urination, the lower center of the spinal cord and the higher center of the brain. After a certain amount of urine is stored in the bladder, the pressure in the bladder begins to rise, creating the urge to urinate. The lower centers of the spinal cord perceive the urge to urinate and upload the signal of urge to urinate to the higher centers of the brain. The higher centers of the brain feed back to the lower centers of the spinal cord when they determine the right time and place, and then the lower centers of the spinal cord command the bladder to start urinating. In normal people, if the urge to urinate occurs during sleep, the signal of the urge to urinate uploaded by the lower spinal cord center can fully awaken the brain, and the person awakens, completes the action of urination, and then goes to sleep. However, in children with frequent enuresis, there may be a small deficiency in the lower spinal cord centers, and the signals from the lower spinal cord are slightly weaker than normal. During the day, when a person is awake, the brain is perfectly capable of perceiving the relatively weak signals from the lower centers of the spinal cord to urinate and control urination well. After sleep, however, the brain has difficulty perceiving the relatively weak signals from the lower spinal cord centers as it shifts to an inhibited state. The lower spinal cord centers act on their own to complete urination when the pressure in the bladder rises to a certain level, given the delay in receiving feedback instructions from the higher centers of the brain. As the child grows, his or her sleep depth will gradually decrease and the higher centers of the brain will gradually adapt to the relatively weak urinary signals transmitted by the lower centers of the spinal cord so that he or she can get up to urinate normally during the night. This is the reason why children who wet the bed can gradually get better, or even disappear completely, as they get older. Therefore, for this group of children, too much medical intervention is not needed. If the child has a bad psychological condition such as nervousness, consider trying some medications that can increase the excitability of the central nervous system, such as chlorate awakening. These medications can increase the excitability of the higher centers of the brain, which can sense the relatively weak signals of urinary urgency that are transmitted from the lower centers of the spinal cord. The child can then awaken on his own or with parental help to urinate. The adverse effect of these drugs is that the child may have difficulty sleeping, but this can be reduced by decreasing the dosage of the drug. Also, these drugs are very well tolerated, and their effects diminish over time. The difference between individuals is also quite large. Therefore, my advice for such children is to control the intake of liquids after dinner; take the drug before bedtime, such as Clorox awake. The dose can be started with half a tablet and gradually increased. The ideal result is that the child can wake up on his own or be awakened relatively easily to go to urinate, but without having difficulty falling asleep. If the child has difficulty sleeping, the dose is too high, and if the child still has great difficulty waking up, the dose is too low. Therefore, the dosage of the medication can be adjusted on its own. Of course, for those who also have unfavorable control of urination during the day, the appearance of soiled feces, sudden urine loss, reappearance of urine loss after it has disappeared, or the presence of thick and thin asymmetry of the lower extremities, a very detailed examination, including magnetic resonance imaging of the lumbar spine, urodynamics, anorectal manometry, and electromyography, is needed to determine the presence of neurological disorders and then take the necessary therapeutic measures.