Generally, it is recommended to start taking oral folic acid in the first trimester of pregnancy and continue until the third trimester when it can be discontinued. Folic acid supplementation during pregnancy is mainly used to prevent fetal neural tube abnormalities, such as anencephaly, spina bifida, and spinal bulge. If there is no history of adverse pregnancy and delivery and other high-risk factors, it is recommended to take 0.4mg of folic acid daily from the time of pregnancy preparation until the first trimester, when the fetus is basically formed and can be discontinued. If you have a history of adverse pregnancy and childbirth, especially a history of fetal neural tube abnormality, you can increase the dose of folic acid supplementation from the first trimester to the whole pregnancy, taking into account your own situation and consulting a professional doctor. During pregnancy, you should take folic acid supplements under the guidance of your doctor, take more rest, work and rest regularly, get enough sleep, enhance nutrition, eat more fresh vegetables and fruits rich in vitamins, and keep your mood relaxed. Do pregnancy checkups on time to understand the growth and development of the fetus.