As the saying goes, “Toothache is not a disease, but pain can kill you.” In fact, toothache can not only be caused by tooth decay itself, many systemic diseases can also cause toothache, which should cause people to pay attention to. 1.Acute and chronic maxillary sinusitis: maxillary sinusitis often causes pain in maxillary molars and premolars. This pain is light in the morning and aggravated in the afternoon or after sitting for a long time. Most patients do not have any damage to their teeth, and most patients have a history of colds before. 2, jaw bone tumor: jaw bone swelling with odontogenic tumor is common, and tumor in deeper parts such as maxillary sinus and pterygopalatine recess is often not easy to detect. When you encounter unexplained toothache, loose teeth, loss of teeth, etc., do not think that it is periodontitis and do not take it lightly, not to mention hastily pulling out the teeth, you should carefully search for the real cause of toothache. 3.Trigeminal neuralgia: atypical trigeminal neuralgia often manifests as toothache in the early stage. When the patient eats, speaks or brushes his teeth, individual teeth cannot be touched, manifesting as sharp pain, electric shock-like, knife-like, pinprick-like pain, lasting for several seconds, unbearable pain, precise location, sometimes radiating, relieved at night, ranging from several to dozens of attacks per day. 4.Temporomandibular joint disorder: the pain is mostly around the temporomandibular joint area in front of the ear and the chewing area, and it is aggravated when eating, and some patients also feel pain in the ear when eating and chewing. Sometimes there is a popping sound in the joint area when opening and closing the mouth, and it is mistakenly thought to be caused by dental diseases. 5.Glottopharyngeal neuralgia: The nature of pain is similar to trigeminal neuralgia. The pain site mostly occurs in the tonsils, tongue root or soft palate, etc. It can be triggered when talking, coughing, swallowing or head twisting, and sometimes it can be misdiagnosed as tooth pain. 6, cardiogenic toothache: coronary heart disease (angina pectoris, myocardial infarction) with toothache as the first symptom is not uncommon in clinical practice, sometimes there are obvious multiple toothaches (posterior toothache), which are persistent, the radiating site of pain is often the left shoulder left arm, neck and face, the pain is aggravated after exertion and reduced after rest. 7, psychological toothache: this kind of toothache has nothing to do with organic dental disease, that is, before the onset of toothache, there is no obvious gingivitis or periodontitis, but is caused by mental factors such as irritation, sadness, tension, etc. It is characterized by the onset of toothache after mood swings. It is mostly seen in emotionally sensitive young and middle-aged people, and is more common in introverted women. 8, intracranial tumor: some brain tumor patients have sensory nerve disorder due to tumor compression of nerves, and experience maxillary or mandibular posterior molar pain, which is sometimes misdiagnosed as trigeminal neuralgia. In addition, there are also some rare clinical toothaches with toothache as the first symptom of pediatric acute leukemia, thyroid disease, and herpes zoster virus-induced infection. Therefore, the statement “toothache is not a disease” should be changed to “toothache can be a very complex disease”.