The conversion of minor triple yang to 2 and 5 positive may be caused by mutation of the hepatitis B virus and clinical cure of hepatitis B. When the hepatitis B virus mutates, it may cause hepatitis B minor triple positive to turn hepatitis B 2 and 5 positive. At this time, although the hepatitis B surface antigen turns negative, the hepatitis B viral load is still positive, and you are still a hepatitis B patient. Liver function and liver ultrasound are needed to assess whether treatment is needed, otherwise it may still progress to cirrhosis and liver cancer. Some Hepatitis B minor triple positive infected patients achieve Hepatitis B surface antigen conversion through autoimmunity or medication to clear the virus, and develop Hepatitis B surface antibody, and turn into Hepatitis B 2 and 5 positive. This situation belongs to the clinical cure of hepatitis B. At this time, the viral load of hepatitis B is negative, and it is enough to maintain regular review in the later stage. It is recommended that the patient should consult the Department of Infectious Diseases in time.