Smoker’s disease, also known as skull base anomalous vascular network disease, is a vaso-occlusive cerebrovascular disease. Specifically, chronic progressive stenosis or occlusion of the major branch vessels of the cerebral arterial ring bilaterally – the end of the internal carotid artery, the anterior cerebral artery, the middle cerebral artery, and sometimes the beginning segment of the posterior cerebral artery – secondary to compensatory skull base penetrating arterial The anomalous network of small vessels in the skull base is formed. These abnormal small vessel networks appear as a smoke-like mass on cerebral angiography, which is why the disease has been called smoggy disease by Japanese scholars. The consequences and dangers of intracranial arterial occlusive smog are very serious and may lead to cerebral ischemia, cerebral infarction, cerebral hemorrhage, seizures, and even more serious life-threatening conditions. A medical expert summarized the consequences and hazards of smog in his paper “Overview of Smog” as follows: 1. Cerebral ischemia (1) can manifest as transient cerebral ischemia (TIA), reversible neurological deficit (RIND) or cerebral infarction. (2) TIA attacks are often associated with excessive stress, crying, stressful emotional reactions, strenuous exercise, meals, excessive cold or heat. (3) Motor impairment is often an early symptom, accounting for about 80.5%, mainly manifested as limb weakness or even hemiparesis, often with the triggering factors mentioned above. It is seen in patients with TIA or cerebral infarction. 3. Cerebral hemorrhage Cerebral hemorrhage is the first symptom, mostly seen in adults. Due to different pathological development, it can be manifested as intraventricular hemorrhage, intracerebral hemorrhage and subarachnoid space hemorrhage. Sometimes, due to the large amount of bleeding or the proximity of the bleeding site to important structures, patients are often accompanied by severe neurological dysfunction and impaired consciousness. The cause of cerebral hemorrhage is mostly thought to be the rupture and bleeding of tiny aneurysms or smoke vessels at the base of the brain formed by the impact of blood flow on the vessel walls as we grow older. 4, involuntary movements involuntary movements usually appear in one side of the limb to show dance-like movements. Facial involuntary movements are less common in smoldering disease, and the involuntary movements disappear during sleep. 5.Headache Some patients have headache. The cause of headache is estimated to be related to reduced intracranial blood supply. Clinically, many smog patients with headache disappear on their own after revascularization surgery. 6.Epilepsy Some patients start with seizures, which can be partial or generalized grand mal seizures. Some patients with smog have decreased IQ to varying degrees due to cerebral ischemia. According to Matsushima typing, the average IQ of type I is 111.4, that of type II is 88.9, that of type III is 68.9, and that of type IV is 63.9. This shows that the more severe the degree of cerebral ischemia, the greater the impact on IQ. IQ measurements and developmental measurements made before and after treatment of patients can help in the evaluation of the effect of surgery. The consequences of this intracranial arterial occlusion smog are very serious and frightening, and should be treated as soon as possible. Currently, the most effective treatment for smog is combined vascular bypass surgery. Combined vascular bypass surgery is a composite procedure, which combines direct vascular bypass surgery and patching in the same surgery. While establishing blood bypass channels through direct bypass, multi-factor patching is performed on the brain surface to induce neovascularization and further expand the scope of blood supply improvement, with a two-pronged approach to achieve a good therapeutic effect.