The pathogenesis of duodenal bulb ulcers is complex, mainly related to the defense of the mucosa and the invasion of the damaged mucosa, the specific etiology is as follows: 1, excessive secretion of gastric acid: excessive secretion of gastric acid is the most important factor in the formation of duodenal bulb ulcers; 2, damaged mucosal barrier: damage factors such as taking drugs (such as aspirin, anti-inflammatory pain, corticosteroids, etc.), rough food or inspection instrument damage, etc., are can weaken the resistance of the mucosa, resulting in mucosal edema, bleeding, erosion, resulting in the occurrence of ulcers; 3, Helicobacter pylori infection: Helicobacter pylori and the development of ulcers; 4, genetic factors: some people with low duodenal function, prone to ulcer-like diseases; 5, poor dietary habits: consumption of cold, greasy, irritating food, excessive alcohol consumption, irregular diet, etc. can cause ulcer-like 6, mental state: long-term tension, anxiety, anger, depression; 7, other diseases: stress ulcers, pancreatic origin ulcers, etc.