The day before yesterday, I talked to a friend about a very sensitive doctor-patient relationship issue, that is, he has a relatively serious allergic conjunctivitis, after a hospital visit, the doctor gave tobramycin dexamethasone eye drops for topical use, two days later he felt better, but his doctor asked him to go to a follow-up appointment, he asked me if there was something fishy about it? Originally, I was disgusted, but I often have complaints from patients with post-surgical or allergic conjunctivitis in my own clinic that their doctors always ask for follow-up after using hormonal eye drops. Therefore, I feel that it is necessary to clarify this issue. We often say that hormones, also known as glucocorticoids, can be taken orally, intravenously and topically, of which the most topical use is in dermatology and ophthalmology, and have a good anti-inflammatory, anti-itch, reduce conjunctival congestion effect. For our ophthalmology, hormones can reduce symptoms faster in the treatment of spring conjunctivitis, chronic conjunctivitis, allergic conjunctivitis, anterior uveitis and other eye diseases; the use of hormones after cataract, vitreoretinal surgery and myopic excimer laser and other eye surgeries can effectively reduce the inflammatory response and promote recovery. Therefore, they are more commonly used in clinical practice, and many people even buy them from pharmacies on their own, leading to improper use or even abuse. However, there are two sides to the coin. While hormones have the above-mentioned good effects, they also have significant adverse reactions, the most serious of which is to cause hormonal glaucoma, that is, secondary open-angle glaucoma (elevated intraocular pressure and impaired visual function) caused by long-term local or systemic use of hormones, which will be irreversible if the treatment time is missed. In addition, the role of hormones is often only to control the symptoms, not to remove the cause, and can also reduce local resistance, induce drug cataract, cause or aggravate fungal keratitis and herpes simplex keratitis, etc. If used for a long time in order to alleviate the symptoms, the disadvantages are obvious and should be carefully considered before purchase and use. And this is exactly what doctors are concerned about. Therefore, for the use of hormonal eye drops, we need to remind you should pay attention to the following points: 1. Anyone who is hypersensitive to hormones must be careful with hormonal eye drops (cream) drops. Hormone hypersensitive people include patients with high eye pressure or glaucoma, highly myopic patients, juvenile diabetics, and those with a family history of glaucoma. If hormones must be used, low concentrations of flutrione, cortisone, and hydrocortisone with poor corneal permeability should be chosen, but close observation is still required. The best choice is to use non-steroidal anti-inflammatory drugs, such as pralofen, diclofenac sodium, etc. 2.When using hormone eye drops, we should strictly grasp the indications, choose the lowest effective concentration, choose the drug with the least adverse effects, and strictly control the number of times and the duration of use. 3, regular review and monitoring of intraocular pressure. For those who cannot stop using hormonal eye drops for more than this period of time, the medication should be administered under the guidance and monitoring of an ophthalmologist, and it is best to test the IOP once a week, and once the IOP is found to be elevated, the medication should be stopped immediately and other types of drugs should be used instead. 4, for hormone-induced IOP increase and glaucoma, its treatment is generally preferred to stop the drug, no special treatment is needed, if the IOP is high, can be localized with eye pressure lowering eye drugs, the majority of its symptoms can be expected to gradually eliminate within a month after stopping the drug. For a very small number of people with persistently elevated IOP, anti-glaucoma surgery is feasible to lower IOP and improve symptoms.