In the case of mitral valve prolapse combined with severe closure insufficiency, if there are symptoms of post-activity shortness of breath, surgery should be performed as early as possible to perform valvuloplasty or replacement of the artificial valve according to the characteristics of the valve lesion, and early surgery is recommended for asymptomatic patients with the following conditions: (1) left ventricular ejection fraction (LVEF) 30-60%, or left ventricular end-systolic diameter ≥40 mm; (2) normal left ventricular function, mitral regurgitation Yao Jianmin, Department of Cardiac Surgery, General Hospital of Beijing Military Region, or with atrial fibrillation or pulmonary hypertension (pulmonary artery systolic pressure >50 mmHg at rest or >60 mmHg after exercise); (3) those with normal left ventricular size, plasma natriuretic natriuretic peptide B ≥31 pg/ml, or cardiopulmonary reserve lower than 84% of the expected value for the same age and sex. Asymptomatic individuals without the above conditions can be closely followed up and observed. Close follow-up observation includes clinical and ultrasound examinations, and it is recommended to follow up every 3-6 months at the beginning in order to have more stable information about the patient. If the patient’s data change from previous data during follow-up or if the data approach surgical indications, the follow-up interval should be shortened. Valve replacement or plication is now a proven technique with a success rate of more than 98%.