Generally speaking, major triple positive is more likely to cause liver damage than minor triple positive. Major triple positive refers to three positive items of Hepatitis B surface antigen (HBsAg), Hepatitis B e antigen (HBeAg), and Hepatitis B core antibody (anti-HBc), and these three positive indexes tend to suggest that the virus in the body is more actively replicating and more contagious, and it is also easy to cause liver cell destruction and hepatitis. Minor triple positive refers to hepatitis B surface antigen (HBsAg), hepatitis B e antibody (HBeAb), hepatitis B core antibody (anti-HBc) three positive, compared to the major triple positive, minor triple positive generally low viral activity, weak contagious, and is not prone to hepatitis complications. However, relying solely on hepatitis B markers to assess the status of hepatitis B is incomplete, and needs to be combined with liver function, liver ultrasound and the patient’s self-perceived symptoms to comprehensively determine whether there is liver damage. Therefore, both patients with triple positive and triple positive need to regularly review the hepatitis B markers, liver function and liver ultrasound to assess their condition.