1. Overview: The incidence of trigeminal neuralgia accounts for about 47.8/100,000 of the total population, with more women than men and a high incidence on the right side. Onset characteristics: ① sudden onset and stop. ②Lightning-like, knife-like, burning-like. (③) Intractable, intractable and severe pain. ④It can be triggered by wiping the face, eating and talking. It is called the “world’s first pain”. 2. There are various treatment techniques, each with its own advantages and disadvantages. (1) Using the pro-neurophilic and anti-axoplasmic transport properties of adriamycin, the drug is injected around the nerve trunk to enter the ganglion cells and achieve the purpose of trigeminal ganglion destruction. (2) Case selection: 15 patients with trigeminal neuralgia, age 40-82 years, duration of disease 8 months-30 years, mean VAS >6 points. All patients were treated with carbamazepine, gabapentin, nonsteroidal analgesics, opioids, etc., with poor results or intolerable drug side effects. (3) Methods: CT or X-ray guided, local anesthesia under local anesthesia with 7#10cm needle puncture for localization. After reaching the foramen ovale, give 1% lidocaine 0.5ml, test the plane and give 0.3-0.5ml of adriamycin. (4) Efficacy observation: ①The patient can reduce or stop the drug if the remission is more than 50% on the day of treatment and the VAS score is less than 3 points in 3~10 days. ②The effective rate after treatment is 90% ③Adverse effects: the incidence of facial hyperalgesia is 22%, and the incidence of facial swelling and hematoma is 6%. It can recover on its own or after symptomatic treatment. (5) Short hospitalization time: 3-5 days; low cost; safe, minimally invasive, low incidence of adverse reactions; obvious effect.