The change of minor bi-positive to minor tri-positive indicates that the replication of hepatitis B virus is more active and the condition is aggravated. You should complete the systematic examination under the guidance of professional doctors, and determine whether the liver function is normal or not by combining the results of the examination. If the liver function is abnormal, you should cooperate with doctors to carry out antiviral treatment in time. 1. Improve the relevant examination: when small binary yang becomes small triple yang, it is necessary to cooperate with the doctor to improve a series of examinations, including blood routine, coagulation four, liver function, hepatitis B DNA, alpha-fetoprotein and abdominal ultrasound, etc., so as to clarify the liver function and the replication situation of hepatitis B virus, etc. If the liver function is normal, hepatitis B virus replication situation should be clarified. If liver function is normal, hepatitis B virus replication is not active, the condition is relatively stable, no treatment is needed. 2. Antiviral treatment: If hepatitis B virus replication is more active, causing liver damage and liver function abnormality, you should cooperate with professional doctors to carry out antiviral treatment as soon as possible, and commonly used medicines include entecavir, tenofovir, etc., which can inhibit the replication of hepatitis B virus. If small two-positive becomes small three-positive, it is recommended to cooperate with the doctor as soon as possible to carry out the relevant examination, and after the diagnosis is clear, the next step of treatment will be taken in a timely manner.