A brainstem hemorrhage that keeps the patient unconscious is mainly caused by the relatively important location of the brainstem and the large amount of hemorrhage. If acute hydrocephalus is present, external ventricular drainage can be provided to relieve the symptoms of increased intracranial pressure. If the condition is stable, early interventional rehabilitation is required to facilitate the patient’s recovery. The main means of rehabilitation treatment include Chinese acupuncture, physical therapy, hyperbaric oxygen, neuroelectric stimulation, music therapy, etc. In addition, medications can be used to promote awakening, such as naloxone and brain-awakening medication. At the same time, nutritional support should be strengthened, because brainstem hemorrhage has a high nutritional demand, and sufficient energy must be supplied according to the standard of 30 Kal/kg/d in the acute stage, which is beneficial to the patient’s recovery.