Extensive follicular hyperplasia of the small intestine is considered to be caused by mesenteric lymphadenitis, small intestinal polyps and other diseases, and can be treated with drugs such as cefixime and phenethylpiperidine. 1. Mesenteric lymphadenitis: Brennemann syndrome is an inflammatory disease caused by bacterial, viral, fungal and other infections of the mesentery, which leads to pathological changes of the small intestinal mucosa, such as congestion, edema and extensive follicular hyperplasia. For bacterial infection, cefixime can be chosen; for viral infection, ribavirin and ganciclovir can be chosen; for tuberculosis infection, streptomycin and ethambutol can be chosen for treatment. 2 small intestinal polyps: can be caused by immunity, genetics, infection and other factors of small intestinal mucosal surface bulging lesions, causing abdominal pain, nausea, vomiting, abdominal distension, diarrhea and other symptoms, you can choose phenyl ethyl piperidine, montelukast and other drugs for antidiarrheal treatment as well as mesalazine, levofloxacin and other drugs for anti-infective treatment. Patients with extensive follicular hyperplasia of the small intestine are advised to consult a doctor for diagnosis and targeted treatment. In addition, all of the above drugs should be used under the guidance of a doctor and should not be taken without authorization.