The duration of isotretinoin treatment for acne needs to be determined by the patient’s condition and individual constitution. 6 to 8 weeks is a course of treatment. Isotretinoin is used for severe refractory nodular acne (where the inflammatory damage is ≥5mm in diameter and may bleed or become suppurative). The adverse effects of using isotretinoin are more pronounced, so it is chosen when other treatments have failed. The dosage can be adjusted according to the effect of the medication in 2 to 4 weeks, 6 to 8 weeks for a course of treatment, and after stopping the medication for 2 months, if the disease still exists, the medication can be continued for another course of treatment. During the period of taking the drug and before and after the three months must be strictly contraceptive. Nursing women are strictly prohibited from using it. Acne patients can apply topical medication, such as retinoids, benzoyl peroxide, erythromycin ointment, and systemic medication is mainly used for moderate to severe acne such as isotretinoin and glucocorticoids. To treat acne, medication should be used under the guidance of a doctor, and should not be used on its own, so as not to delay the condition.