Many patients with pancreatic cancer, hepatocellular carcinoma and other abdominal tumors often suffer from severe pain, which is sometimes difficult to achieve the desired effect even after treatment with a large number of pain medications. The commonly used opioid painkillers often have side effects such as constipation, nausea and dizziness. At this time, there is a great limitation in applying painkillers alone. In addition to pharmacological pain relief, what other problems should be noted in the treatment of intractable pain of advanced abdominal tumor patients? Only when the tumor is controlled, the pain can be relieved at all. According to the specific condition, we can choose surgery, radiotherapy, chemotherapy, interventional minimally invasive therapy, biological therapy, immunotherapy and so on. Secondly, Chinese medicine acupuncture, acupoint injection for pain relief, music therapy and other methods with small side effects and low cost can also be involved in pain relief, and sometimes can achieve obvious curative effect. A patient with hepatocellular carcinoma in the ward took oral oxycodone hydrochloride 20mg q12h after interventional treatment, but the pain was still unsatisfactorily controlled, so I gave him additional pain relief aid by acupuncture point injection of huachansu, and obtained good results. Third, if the above methods are not satisfactory, minimally invasive interventional pain relief can also be considered, such as the author’s use of abdominal plexus chemical destruction for treatment of intractable pain caused by upper abdominal tumors such as hepatocellular carcinoma and pancreatic cancer, which can achieve immediate pain relief with low cost and reliable efficacy and avoid the high cost of long-term drug pain relief. Surgical route: Under CT or ultrasound guidance, the needle is inserted from the abdomen/or back, and the puncture needle avoids organs such as liver, stomach and intestine, and finally reaches the location of the abdominal plexus in the anterior part of the aorta, firstly giving a 2% lidocaine bureau 5ml injection, and then injecting 10~15ml of anhydrous alcohol when the patient complains of abdominal pain relief and the decrease in blood pressure is detected by cardiac monitoring, suggesting the accurate location of the needle tip. General complications: including Hypotension and increased gastrointestinal motility. Hypotension is a result of visceral vasodilation, and preoperative fluids and close blood pressure monitoring should be performed, especially before the patient stands, to avoid upright hypotension. Increased gastrointestinal motility may help avoid constipation in patients treated with opioids for analgesia by modulating bowel habits. However, severe diarrhea has been reported, which may be the result of vagal excitation. Typical case report The patient was a 57-year-old male with hepatic and retroperitoneal lymph node metastasis from esophageal cancer. He had severe abdominal pain and was unable to lie down. The next day, the pain medication was immediately reduced to OxyContin 10mg Q12H. Figure 1, CT-guided puncture needle reaching the vicinity of the abdominal plexus; Figure 2, after injection of anhydrous alcohol iodized oil emulsion