Chronic leakage of amniotic fluid for more than 12 hours is a certain risk, and in principle, it should not exceed 24 hours. If the amniotic fluid leakage time is too long, the following situations may occur: 1. intrauterine infection: chronic amniotic fluid leakage is actually a high level of premature rupture of fetal membranes, pathogenic bacteria can easily invade and cause intrauterine infection, which can lead to chorioamnionitis, which in turn leads to aspiration pneumonia, intracranial infection and sepsis in the newborn, etc. As the time of rupture of membranes is prolonged, the chance of maternal infection will increase accordingly; 2. too little amniotic fluid: the amount of amniotic fluid in the uterine cavity gradually decreases. In addition, it is not easy to induce labor when terminating a pregnancy, thus increasing the rate of cesarean section; 3, placental abruption: after the rupture of the fetal membrane, the pressure in the uterine cavity may change, and some pregnant women may experience placental abruption, resulting in premature labor. The shorter the gestational week, the less developed the fetus is and the greater the chance of immature fetal lungs. In case of full-term premature rupture of membranes, the condition of mother and child should be evaluated, including the presence of fetal distress, chorioamnionitis, placental abruption and umbilical cord prolapse. Prophylactic antibiotics should be applied more than 12 hours after rupture of membranes. If there is no clear indication for cesarean delivery, active induction of labor should be performed within 2-12 hours after rupture of membranes. In case of preterm premature rupture of membranes, a comprehensive decision should be made based on the gestational week, maternal and child status, local level of neonatal care and the wishes of the pregnant woman and her family, and termination of pregnancy should be considered if the benefits of termination outweigh the expected treatment.