When it comes to erosive staphyloma and choriocarcinoma, they may be unfamiliar to you, so I would like to introduce them below to let you know a little bit about this disease. Before the 1950’s and 1960’s, hospitals at home and abroad mainly treated them through surgery, and the treatment effect was extremely poor, and the mortality rate basically reached 100%. After the 1950s and 1960s, obstetricians and gynecologists from all over the world jointly researched and found that chemotherapy can have better effect and the mortality rate has been significantly controlled. 1. What are the symptoms of these malignant tumors, such as erosive staphyloma and choriocarcinoma and trophoblastic tumors of the placenta? How can we detect them? Eruptive staphyloma, or malignant staphyloma, is a trophoblastic tumor, along with choriocarcinoma and trophoblastic tumors of the placenta, and the symptoms and treatment options for the first two diseases are basically the same. They both present with abnormally high HCG and are mostly diagnosed by finding suspicious metastases in the myometrium or parametrium, vagina, adnexa, vulva, lung, brain, etc. before or after treatment for choriocarcinoma. The initial symptoms of such patients are mostly abnormal menstruation, amenorrhea or irregular vaginal bleeding, and the HCG is significantly higher than normal or even over one million. 2.How should we look at erosive grapevine and choriocarcinoma correctly and cooperate with the doctor’s treatment? At present, the general treatment options in China are monotherapy without fluorouracil, combination chemotherapy with pentafluorouracil and vincristine, or EMACO, and if brain metastasis occurs, intrathecal injection should be added. Surgery is not usually considered. If the patient has an acute abdomen or severe bleeding that requires emergency surgery to stop bleeding and rescue, surgery while chemotherapy may be considered. A few other patients are diagnosed intraoperatively or postoperatively and may require extensive blood preparation during surgery. Trophoblastic disease at the placental site, however, is poorly treated by chemotherapy and is mainly treated by surgical excision. It is not uncommon for some young patients to have abnormal menstruation at the early stage of the disease, which does not attract enough attention from both patients and their families to visit the gynecology department and wait until symptoms of other metastatic sites such as lung and brain appear before visiting the relevant departments. Most patients with trophoblastic tumors can be cured by chemotherapy. The key to treatment is timely, standardized, adequate amount and full course of chemotherapy, the so-called timely standardization and early chemotherapy after diagnosis, the standardization of the treatment plan chosen, the time of each treatment according to the prescribed cycle, and the failure of chemotherapy on time due to human reasons will have certain influence on the treatment effect. The longer the interruption time, the greater the chance of drug resistance. After this kind of disease, the standard several times or more than ten times chemotherapy to HCG stable in the normal value, ultrasound or CT image no significant changes and then consolidate one to two courses of treatment can be discontinued, after discontinuation of the drug need to be strict contraception and close follow-up for at least two years without recurrence, can be followed up once a year to five years, there are many young patients after two years normal childbirth, follow-up for more than ten years the disease has not seen a recurrence. So, this highly malignant disease is no longer so terrible as long as we all pay attention to it.