1, sleeping pills class: Sleeping pills such as Sleeping pass, quick sleep, sodium phenobarbital have enzymatic effects, will reduce the effectiveness of oral contraceptives. Therefore, when you need to use sleeping pills, you can use Valium. 2, anti-rheumatic drugs: such drugs also have enzymatic effects, can accelerate drug metabolism, so that the contraceptive pill to reduce the effectiveness of contraceptive failure. So, with anti-rheumatic drugs, should increase the dose of contraceptive pills, or stop using contraceptives using other contraceptive methods. 3, antihypertensive class of drugs: oral contraceptives containing estrogen, with enhanced lisinopril, methyldopa stimulate the role of lactogen secretion, can cause breast enlargement and lactation symptoms. 4, antipsychotic drugs: the situation is similar to the antihypertensive drugs. 5, anticoagulants: such drugs can inhibit the synthesis of prothrombin and coagulation factors in the body, and the contraceptive pill can enhance the coagulation effect, thereby reducing the effect of bicoumarins, so it is not advisable to take oral contraceptives during the use of anticoagulants. 6, insulin: contraceptives can promote the deterioration of diabetes, improve the patient’s need for insulin, and may increase the incidence of complications of cardiovascular system disease in diabetic patients. Therefore, diabetic patients should not use oral contraceptives contraception. 7, corticosteroids: oral contraceptives can increase the efficacy of corticosteroids (prednisone, dexamethasone, etc.), slowing down their metabolism, so that their role and side effects are enhanced. Therefore, when both are taken at the same time, the dose of corticosteroids must be reduced. 8, tricyclic antidepressants: promethazine is a tricyclic antidepressant, if taken at the same time with the contraceptive pill, can compete in the liver common metabolic enzymes, and the antidepressant in the body to slow down the metabolic rate and prolong the duration of action. Therefore, when the two are taken together, the dose of tricyclic antidepressants should be reduced.