An atrial septal defect is a hole located between the right and left atria. Its treatment is to close this hole surgically or by using a blocker. Open-heart surgery has its advantages as a traditional treatment modality, but less trauma is also sought by both the doctor and the patient. Percutaneous intervention to seal the atrial septal defect can be very effective in appropriate cases and at the same time very minimally invasive. For children who can cooperate with the procedure, it can be done under local anesthesia, leaving only a needle hole at the base of the thigh after the procedure, and they can be discharged about 3 days after the procedure. In contrast, open-heart surgery leaves scars on the chest, requires general anesthesia for extracorporeal circulation, and requires admission to the ICU after surgery. However, minimally invasive is not the goal; the goal of both the doctor and the patient is to cure the disease. Percutaneous interventional occlusion is also not suitable for all cases. First, such a case should be a simple atrial septal defect, or at least not combined with other congenital heart disease conditions that cannot be treated by intervention. There may be some error between the transthoracic echocardiographic findings and the actual defect, which should be further evaluated by means of transesophageal echocardiography if necessary, meaning that the echocardiography suggests that the defect can be sealed, but there is a real possibility that the seal may not be successful. Secondly, it should be a secondary foramen ovale central septal defect, and the septal defect is not simple, there are primary foramen ovale septal defects, non-central secondary foramen ovale septal defects, and non-apical coronary sinus syndrome. Again, the defect should not be too large or too partial, but preferably only one hole, i.e., it is best if the “hole” is located right in the center of the septum and at a certain distance from important structures such as the upper and lower vena cava, pulmonary veins, coronary sinus opening and mitral tricuspid valve on all sides, so that it can be stuck in the plug-like blocker. Finally, the consultation should be prompt, and if there is already severe pulmonary hypertension, or even Eisenmenger syndrome, that is a separate discussion. Tip: Minimally invasive is not the same as minimally risky, much less zero risk. Adverse outcomes that have been reported include inability to complete the blocking operation, dislodgement or displacement of the blocker, cardiac perforation, residual shunt, aortic atrioventricular fistula, thrombosis of the blocker surface, and general complications of the intervention. However, for appropriate cases of atrial septal defect, I preferentially recommend percutaneous interventional occlusion therapy.