We recently performed a case of non-radiographic intervention via femoral vein with simple chest surface echocardiography-guided closure of an atrial septal defect. The patient recovered well after the operation and was discharged on the second postoperative day. 1. There are two methods of minimally invasive interventional procedures for the treatment of atrial septal defects. The cardiologist performs the blocking treatment through the femoral vein (puncture at the root of the thigh, which usually does not leave a wound after the operation) under X-ray fluoroscopy in the catheterization room. However, it is known that radiation is very harmful to the body, especially to the reproductive system and thyroid function. It is also very harmful to the hematopoietic and bone marrow systems of young children and children. 2, general surgical minimally invasive intervention is done through a 2-3cm incision between the 3rd and 4th ribs next to the sternum to complete the umbrella blockage treatment. Although the danger of radiation is avoided, unfortunately, it will leave a permanent scar on the right chest wall, which is a pity for young, especially unmarried or special occupation patients. 3. We have completed 5 consecutive cases of atrial septal defect occlusion with transesophageal echocardiographic guidance via non-radiographic intervention in the femoral vein, and all of them were successful. However, because of the potential damage to the larynx and the need for general anesthesia due to the insertion of an ultrasound probe through the esophagus, we continued to improve our surgical approach and successfully completed atrial septal defect closure for a 63-year-old female patient under basic anesthesia (no general anesthesia without tracheal intubation and esophageal probe) and extracorporeal echocardiographic guidance (no radiological damage). This is the best procedure for treating atrial septal defect with minimal damage to human body and at the same time ensuring a high success rate, which is worth promoting vigorously to provide a safe and green surgical approach for more patients with precordial disease. The list above illustrates that the non-radiological surgical umbilical block is “none” in general anesthesia, esophageal ultrasound, radiation hazard and chest incision, which is the least damaging. It is the least invasive procedure for the treatment of atrial septal defects.