There are many causes of dull, aching pain in the liver area, and common diseases include liver diseases, gastrointestinal diseases, biliary system diseases, etc. It is necessary to choose the appropriate treatment according to the different diseases in order to relieve the symptoms. Commonly used drugs include entecavir, levofloxacin, omeprazole and so on. 1. Liver diseases: such as liver inflammation, liver cancer, etc. At this time, the dull swelling and pain in the liver area is more obvious after exertion, and patients often have jaundice, ascites and other manifestations. Color ultrasound, CT and other related imaging examinations of the liver area can be done to make a clear diagnosis. If the patient is viral hepatitis B, the patient can be treated with drugs such as entecavir tablets and compound glycyrrhizin tablets. 2. Gastrointestinal diseases: pain in the abdominal organs, generally vague positioning, when the occurrence of peptic ulcer, chronic gastritis, stomach tumors and other diseases, may also be manifested in the liver area stuffy hidden pain. Early pain is usually distension and vague pain, and later can develop into severe pain. Omeprazole enteric-coated capsules, bismuth potassium citrate and other drugs can be considered for treatment. 3. Biliary system diseases: such as gallbladder stones, may lead to the liver area stuffy pain, often accompanied by abdominal distension, nausea and other symptoms, in this regard, the need for surgical resection. Inflammation, also need to give ampicillin and other antibiotic drugs for treatment. It is recommended that patients consult a doctor in time to clarify the cause and give targeted treatment, do not blindly self-medication.