Five years after liver cancer surgery, medication should not be abandoned, mainly because the recurrence rate of cancer is high, and should be combined with medication to slow down the progress of the disease. The therapeutic effect after liver cancer surgery is affected by many factors, such as tumor stage, physical condition, treatment method and so on. However, due to the high recurrence rate of liver cancer, even patients with early stage of liver cancer often need to take drugs for a long time after surgery. Therefore usually after 5 years after surgery, drugs should still be used to delay the disease. There are two main types of drug treatment for liver cancer, targeted therapy drugs and immunotherapy drugs. The common ones are sorafenib, lenvatinib, pabolizumab, navulizumab, tirilizumab and so on. Drugs such as tirilizumab are usually recommended to be used until disease progression or intolerable toxicity occurs. It is recommended that patients diagnosed with hepatocellular carcinoma should go to regular hospitals for evaluation and follow-up after surgery, and follow the doctor’s instructions to cooperate with the treatment, so as to control the disease progression and improve the patient’s prognosis. Please strictly follow the doctor’s instructions for drug treatment and do not modify the drug regimen on your own.