The general ultrasound report describing ‘no significant abnormality in the liver’ does not mean that it is absolutely normal. Because of factors such as the resolution of the machine and the condition of the subject, certain microscopic lesions or the early stages of certain diseases cannot be shown on the sonogram of the ultrasound. The description of the liver on the ultrasound report generally includes the morphology and size of the liver, the ductal structures within the liver, and the echogenic manifestations of the liver parenchyma, as well as the detection of the major blood vessels within the liver. In many patients, abnormal liver function is found when blood is drawn for liver function, and then liver ultrasound is performed, resulting in a liver ultrasound that shows no significant abnormalities in the liver. This does not mean that the liver is completely normal, because the abnormal liver function is indicated by the blood test, but the abnormality of the liver is not shown on the ultrasound image. When liver function abnormalities exist, clinician intervention is usually required, so the disease cannot be diagnosed based on liver ultrasound alone. On the contrary, when the liver ultrasound examination reveals minor lesions, such as abnormal liver echogenicity, and then blood is drawn for liver function tests, if the results of liver function tests show normal, regular observation is generally recommended in clinical practice at this time, and no drug intervention is required. Therefore, whether the liver is normal or not is not determined by ultrasound alone, but requires a comprehensive diagnosis combined with clinical and laboratory tests. Therefore, when the ultrasound result shows no significant abnormality, and when other liver-related tests are combined, all of them indicate no significant abnormality, only then can we say that there is no major problem with the liver.