Premature ejaculation at the age of 46 can be cured, and can be treated by drugs (lidocaine, paroxetine, etc.), general treatment and psychotherapy, surgery and other methods under the guidance of a doctor. 1. Drug treatment: can be under the guidance of the doctor, through the use of lidocaine, proparacaine and other drugs for treatment, can reduce the sensitivity of the penis, prolong the time of ejaculation, but also the use of 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine, sertraline and so on. 2. General treatment and psychotherapy: Utilize functional-sexological therapy to prolong the process of sexual intercourse by adjusting the pelvic movement to reduce muscle tension, slowing down the breathing rate, and using abdominal breathing. If necessary, consult a psychiatrist to adjust the psychological state. 3. Surgical treatment: you can selectively cut off the dorsal nerve of the penis, targeting the sensory afferent link in the process of ejaculation, to reduce the sensory afferent, to achieve prolongation of ejaculation time. It is recommended that patients go to the hospital, under the diagnosis of the doctor, according to the patient’s condition performance, to take targeted treatment, life should adjust the mentality, pay attention to perineal cleanliness and hygiene, and actively exercise.