Pre-implantation diagnosis is the process of biopsy and genetic analysis of oocytes or blastocysts fertilized artificially in vitro during the process of assisted reproduction, from which genetically normal embryos are selected for transfer to obtain a healthy next generation, commonly known as third generation IVF. Pre-implantation diagnosis has been successfully implemented internationally for many single gene genetic disorders. The vast majority of hereditary deafness is a highly genetically heterogeneous single gene disorder and is eligible for clinical application of preimplantation diagnosis. For many families at risk of having a child with genetic deafness, the only option before the advent of PGD technology was to prevent the birth of a child with hearing defects by prenatal diagnosis with amniotic fluid or amniotic fluid extraction at 11-22 weeks of gestation. Suitable for: 1. Couples who are deaf gene carriers and have been diagnosed at our Molecular Deafness Diagnostic Center and wish to conceive a normal hearing child through IVF technology. 2.Healthy, no systemic diseases, no reproductive system diseases that are not suitable for IVF treatment. 3, have a certain understanding of the process of assisted reproduction, have reasonable expectations and good compliance. Technical advantages: 1. While performing genetic diagnosis of deafness, we can use whole genome second generation sequencing to perform chromosome aneuploidy and CNVs detection, which can identify chromosome micro fragment abnormalities. It can not only detect and avoid birth defects caused by common chromosomal abnormalities such as Down’s syndrome, but also screen and exclude embryos with complex chromosomal fragment deletions and duplications, avoid as much as possible post-implantation miscarriage and fetal abortion caused by chromosomal abnormalities, and improve implantation survival rate. 2. Using the most advanced international single-cell whole genome amplification technology to improve the homogeneity of amplified DNA products and avoid misdiagnosis caused by gene fragment loss. And through the SNP verification method to further ensure the correct diagnosis. 3.The Center for Reproductive Medicine has internationally advanced embryo biopsy, freezing and resuscitation techniques and rich experience in artificial assisted reproduction technology, which provides a reliable guarantee to improve the conception success rate of pre-implantation diagnosis.