Drug treatment is mainly for prepubescent and adolescent, while drug treatment for adults is ineffective and surgical treatment is recommended. According to the etiology of penile shortening, early targeted endocrine therapy is the first choice. 1.For children with abnormal pituitary function, hCG 500U is used and injected intramuscularly every 5 days for 3 months. 2.For children with abnormal hypothalamic function, direct replacement with gonadotropin-releasing hormone such as LHRH. 3.For children with insufficient testicular secretion, direct testosterone replacement therapy. 4.For patients with Klinefelter syndrome, who are androgen insensitive and have no male pubertal features but have feminized breast signs, coupled with extremely low libido, sex reassignment surgery can be considered if the patients themselves strongly request it. 5. For endocrine treatment is ineffective, penis lengthening can be considered when the penis is poorly developed in adulthood and it affects sexual life.