Human papilloma virus (HPV) is a group of double-stranded DNA viruses that mainly infect human skin and mucous membranes. HPV-associated diseases are receiving more and more attention as the rate of HPV infection is increasing year by year and the risk to human beings is increasing. It is generally believed that high-risk HPV is associated with the development of some tumors, while low-risk HPV is associated with benign skin and genital tract lesions. Different types of HPV can cause different clinical manifestations and different diseases, and worldwide, HPV infection causes the 4th to 5th most common skin disease in dermatology clinics, with a wide range of patients. The number of diseases associated with HPV infection is also increasing, such as Bowen’s disease, Buschke-Lowenstein (BL) tumor, Bowen’s disease, basal cell carcinoma, squamous cell carcinoma, cervical cancer, etc. HPV is rare in terms of the number of diseases it causes, the range of diseases it causes, and the number of risks it poses. The actual fact is that it is not only transmitted through sexual contact, but also through certain contamination routes. Cervical cancer (caused by high-risk HPV infection) is a common gynecological malignancy, with about 500,000 new cases and 250,000 deaths per year worldwide, and in some developing countries it even ranks first in female cancer mortality. In China, there are about 150,000 new cases of cervical cancer each year, and about 80,000 people die from cervical cancer each year, and its mortality rate is the second highest among gynecological tumors. The widespread HPV carriers, subclinical and latent infections are the main reason and the biggest potential danger for the high incidence, recurrence and spread of the disease, and persistent HPV infection is the real root cause of tumor development. HPV virus invades the body and stays in the skin and mucous membranes at the site of infection without producing viremia. The most common clinical conditions are: common warts, also known as prickly warts, can occur in any part of the body, with the hands being the most common; plantar warts grow on the feet and cause pain when walking; flat warts occur on the face, hands, arms, knees, and often multiple; and condyloma acuminata, which occurs in the warm, moist genital area, is highly contagious and is one of the top three sexually transmitted diseases in China. The actual fact is that more than 20% to 80% of the sexually active population has a history of HPV infection. 70% to 80% of women have been infected with HPV during their lifetime, and most of them clear up on their own through their own immunity within 1 to 2 years after infection. Therefore, even if HPV infection is detected, there is no need to be nervous. Regular testing is necessary. Once a skin disease or tumor with HPV infection has been detected, there are corresponding clinical treatments such as surgery, cryotherapy, laser therapy, photodynamic therapy, electrocautery therapy and drug therapy.