There is no drug to activate the secondary proliferation of the corpus cavernosum, if the patient has erectile dysfunction, oral phosphodiesterase 5 inhibitors, such as sildenafil, tadalafil and so on. At present, there is no drug that can secondarily proliferate the corpus cavernosum, if the patient has erectile dysfunction. They should combine their own situation and take oral phosphodiesterase 5 inhibitors, such as sildenafil, tadalafil, vardenafil, avanafil and so on, under the guidance of the doctor. All of the above drug ingredients can prompt the release of nitric oxide in the corpus cavernosum of the penis during sexual intercourse. Nitric oxide, in turn, can activate guanylate cyclase and increase its level, leading to smooth muscle relaxation and increased blood flow in the penis. However, it should be noted that this type of drug is contraindicated in people who are allergic to its ingredients. Some patients may experience adverse effects such as facial edema, fatigue, chills, allergies, vomiting, and tachycardia during the use of phosphodiesterase 5 inhibitors. Therefore, patients should take these drugs under the supervision of a doctor.