Nocturnal itching in the plantar area of the feet is most commonly caused by tinea pedis after fungal infection of the local skin, mostly accompanied by small blisters or mild peeling, in addition to eczema, mostly accompanied by erythema, papules, blisters, vesicles, and exudation, both of which are clinically common and can be observed with care.1. Tinea pedis: It is mainly caused by fungal infection, which can break down the keratin layer during its activity, accompanied by intense itching. A local fungal examination needs to be performed at a hospital and topical antifungal drugs such as bifenazole cream, terbinafine cream, and ketoconazole cream can be chosen for treatment after diagnosis. During the treatment period, it is necessary to avoid wearing wet and stuffy shoes and socks, otherwise it is easy to promote fungal reproduction and affect the treatment effect. Usually need to pay attention to personal cleanliness and hygiene, to develop good habits; 2, eczema-like disease: humidity, sweltering heat or allergies and other factors acting together on the plantar part of the foot can lead to eczema-like disease, laboratory fungal test is negative. Treatment can choose glucocorticoid ointment, such as paregoric ointment, trimethoprim ointment, etc., but also oral anti-allergic anti-itch drugs, such as cetirizine, loratadine, etc.. It is necessary to pay attention to not to wear tight fiber shoes and socks, to keep the feet breathable, and to eat a light diet and avoid spicy and stimulating food.