The effect of combining cold and fever clearing granules with what drugs is good cannot be generalized, and it is necessary to choose suitable drugs according to the patient’s symptoms, which can be combined with acetaminophen and amoxicillin under the guidance of doctors for better treatment effect. Cold and flu are mostly caused by bacteria or viruses, and cold and flu clearing fever granule is an antidote, with the effect of dispersing wind and cold, relieving surface heat, and can be used for wind and cold, headache and fever, vicious cold and body pain, nasal runny nose, cough and dry throat. If the fever is serious, it can be combined with acetaminophen, ibuprofen and other drugs to relieve fever and analgesia, and usually you can also use warm water baths and ice packs for physical cooling. If the symptoms of headache, nasal discharge and generalized soreness are difficult to be relieved, you can pair them with amoxicillin, penicillin sodium, ceftriaxone sodium and other drugs for anti-inflammation and sterilization to relieve the corresponding symptoms with better effect. In addition, you should also pay attention to rest, drink more water, and exercise properly to enhance physical fitness. Diet is recommended to be based on easy-to-digest, high-energy food, such as lean vegetable porridge, tomato and egg noodles, vegetable noodles, etc. Avoid eating too cold, greasy, spicy, irritating food, and not overeating. If medication does not relieve the symptoms and the symptoms continue to worsen, it is recommended to go to the hospital in time.