Panic, chills and shivering may be caused by physiological factors or by pathological factors, such as arrhythmia, hyperthyroidism, hypoglycemia, etc. It is recommended to clarify the cause of the disease and treat according to the cause. 1. Physiological factors: some patients can be stimulated by sympathetic excitation after anger, panic, fatigue and emotional excitement, which causes redistribution of blood flow throughout the body and acceleration of heart rate, resulting in panic, chills and shivering, and the symptoms can be relieved significantly after the disappearance of the above factors. 2. Pathological factors Arrhythmia: due to the abnormal rhythm and frequency of the heart beat, causing panic symptoms, some patients may cause a drop in blood pressure, symptoms of insufficient perfusion of the whole body tissues, chills and shivering. Hyperthyroidism: due to tumor, immunity, inflammation and other factors, the thyroid gland overproduces thyroxine, causing an increase in the basal metabolic rate causing sweating and chilling of the limbs; there is a faster heart rate, panic, and trembling of the hands. Hypoglycemia: some patients may have pancreatic tumors, excessive or wrong taking of hypoglycemic drugs, subcutaneous injection of insulin without timely eating, causing low blood glucose, general weakness, cold and clammy skin all over the body, panic, shivering of limbs and other symptoms. When panic and cold shivering occurs, it is recommended to exclude physiological factors in time. If the condition still flares up after exclusion of physiological factors, it is recommended to go to the hospital in time to get a clear diagnosis and targeted treatment under the doctor’s comprehensive analysis.