Uterine fibroids that become large during pregnancy can be treated conservatively if there are no other symptoms. If red degeneration occurs, timely medical treatment should be sought and the pregnancy should be terminated at the right time. Uterine fibroid is a hormone-dependent disease. During pregnancy, the hormone level in a woman’s body will increase, which will stimulate the fibroid to enlarge gradually. If a pregnant woman has no relevant symptoms, she can take conservative treatment and go to the hospital for regular review in order to observe the fibroid condition. If the red degeneration is caused by the enlargement of fibroid, resulting in severe abdominal pain accompanied by nausea, vomiting and other symptoms, pregnant women should immediately go to the hospital, follow the doctor’s instructions for treatment, and terminate the pregnancy at the right time. Although uterine fibroids is a benign tumor, but because it is affected by the hormone level, uterine fibroid patients after pregnancy, will make the fibroid volume increase, easy to cause miscarriage, placental abruption and other complications. Therefore, before pregnancy, both husband and wife should undergo a comprehensive physical examination, and if uterine fibroids are found, they should be actively consulted before pregnancy.