Prolonged chest tightness and cough may be associated with respiratory and circulatory diseases. Chronic chest tightness and cough are first considered to be caused by respiratory diseases. Pneumonia, chronic bronchitis, bronchial asthma, and pleural diseases such as pleurisy can cause prolonged chest tightness and coughing if not treated in time. It can also be caused by circulatory disorders, including heart failure. It can result in localized circulatory disorders that cause pulmonary stasis, which can also present with chest tightness and cough. Long-term chest tightness and cough may also be related to other diseases, the specific causes need to be clarified after medical examination, and at the same time in accordance with the doctor’s instructions for treatment, to avoid further aggravation of the condition.