Body temperature is an important vital sign that reflects the health status of newborns. The body temperature of newborns is usually around 36℃-37℃, which usually refers to the axillary temperature, and the temperature of the oral cavity and rectum will be relatively higher. Because the newborn’s thermoregulatory center is not yet mature, it cannot reasonably regulate its own body temperature, so when the newborn’s body temperature is too high or too low, it should be corrected in time to avoid affecting health. Accurate measurement of the newborn’s body temperature is essential for early detection of changes in the condition and timely intervention. If the newborn’s axillary temperature is higher than 38°C, active heat treatment is needed, usually by physical cooling or oral ibuprofen suspension, etc., to control the body temperature in the normal range. Secondly, the cause of the baby’s fever should be clarified, and anti-infective treatment such as sodium penicillin or cefotaxime should be used in a timely manner to prevent persistent increase in temperature, which may lead to febrile convulsions and other adverse consequences. And if the newborn’s body temperature is low, it can lead to reduced enzymatic activity in the gluconeogenesis pathway and glycogenolysis pathway, and reduced secretion of glucagon, leading to the occurrence of hypoglycemia, therefore, timely correction of hypothermia is extremely important for the health of newborns.