Regardless of the type of jaundice, it clinically causes yellowing of the skin mucosa as well as the sclera. The more severe the lesion, the more pronounced the color of the jaundice. In addition, jaundice can cause itching of varying degrees, and in severe cases can cause signs of skin scratching and possibly even infection, an itch that is difficult to relieve. The color of the urine may also deepen, even from a strong tea or red wine color. In addition, different causes of jaundice may also have different clinical symptoms, such as hepatocellular jaundice mostly accompanied by fatigue, anorexia, loss of appetite, and the face of chronic liver disease. Obstructive jaundice is more likely to present with symptoms of biliary infection, such as abdominal pain, high fever and chills, and, in severe cases, infectious shock and central nervous system depression. In complete obstruction, the stool may become lighter in color or even white clay-like. Hemolytic jaundice may cause hemoglobinuria and even acute renal failure with oliguria or anuria.