Retinal periphlebitis, also known as Eales disease, is characterized by repeated accumulation of blood in the retinal glass body, mostly in young men, with the most common age of onset being 20-40 years old and rare in women over 40 years old. It is common that both eyes develop successively. The incidence is more in China than in other countries. The main manifestation is a sudden decrease in visual acuity to the index, manual, or even light perception. When the vitreous hemorrhage is absorbed, small veins in the peripheral part of the retina are seen to be dilated, tortuous, congested, surrounded by white sheaths, and with hemorrhages of varying sizes, in sheets, lines and irregularities. There is white exudate in the area of the lesion. As the lesion progresses, it may affect the large veins and progress to the posterior pole, leading to vision loss or blindness. Often, one eye develops and the retinal vasculopathy above is visible in the fundus of the other eye. It is characterized by chronicity and recurrence. Fundus fluorescence angiography shows dilated peripheral veins, tortuosity, fluorescein leakage, capillary non-perfused areas, neovascularization, arteriovenous short-circuiting, and macular edema. The etiology is unclear and is generally considered to be mainly related to tuberculosis. Nearly half of the patients have a history of tuberculosis with inactive or active tuberculosis lesions. Tuberculin test is positive. Others are thrombo-occlusive vasculitis, septic lesions, diabetes mellitus, etc. According to TCM, this disease belongs to the category of loxoplasmosis and is classified as: (1) Qi stagnation and blood stasis (2) Yin deficiency and Yang hyperactivity (3) Phlegm and stasis interconnection (4) Heart and spleen deficiency. Treatment: Western medicine treatment with laser has certain effect, vitreous hemorrhage is feasible when serious vitrectomy. Surgery has certain risks and comorbidities. Based on long-term clinical experience, our department treats this disease with a combination of Chinese and Western medicine quadruple therapy, and has achieved good results, which are introduced as follows: (1) intravenous drip vasodilation, softening of blood vessels, nutritional drugs, improving vascular resistance, promoting blood circulation, helping absorption of bleeding, and preventing neovascularization. (2) Oral Chinese medicine, according to the patient’s specific disease, targeted use of Chinese herbs to regulate Qi, resolve blood stasis, stop bleeding, nourish Yin, pass the ligament, nourish the heart, strengthen the spleen, etc. to perform systemic conditioning. (3) According to the Chinese medicine meridian theory, we use acupoint injection therapy to stimulate the acupuncture points to make the meridians through the eye smooth and restore the function. At the same time, different drugs are injected behind the ball, not only to stimulate acupuncture points, but also to increase the local drug concentration. (4) Local ultrasonic therapy to promote local blood circulation in the eye and increase the local drug concentration (ultrasonic effect is 30 times stronger than the effect of dotting eye water), and local hot compress, physiotherapy effect. With the above therapy plus laser treatment, most of our patients have retinal and fundus hemorrhage absorption, exudation disappeared, vision restored, and the recurrence rate decreased significantly, with minimal side effects, the effect is satisfactory. The combination of Chinese and Western medicine is a safe, reliable and effective method, but long-term follow-up and maintenance treatment are necessary to ensure the efficacy and prevent recurrence. At the same time, to have a certain understanding of the disease and maintain a good attitude and confidence is also essential for the treatment of this disease.