Periocular lipogranuloma can be treated with surgery and medication under the guidance of a doctor. 1. Surgery: patients can under the guidance of the doctor for ionization surgery, the use of ionization to destroy the fat particles, but also can use laser surgery, anesthesia, the use of carbon dioxide laser to burn the fat particles, the patient should pay attention to rest, avoid contact with the wound with water, prohibit spicy and stimulating food. 2. Medication: patients can use mupirocin ointment, erythromycin ointment and other drugs under the guidance of the doctor to apply treatment, this kind of drug is generally used for allergies, bacterial infections caused by inflammation of the skin tissues, overuse of the patient may appear itching, tingling, burning and other symptoms, allergic to mupirocin or other ointment containing polyethylene glycol, patients with allergies to prohibit the use of this drug. Patients should go to the hospital under the guidance of the doctor for reasonable treatment.